Antioxidant Properties of Tonsil-Derived Mesenchymal Stem Cells on Human Vocal Fold Fibroblast Exposed to Oxidative Stress

<div>The dynamic changes in activity and expression of malondialdehyde (MDA) and other antioxidant enzymes. (a–d) The activity and expression of various antioxidant enzymes including superoxide dismutase (SOD), catalase, glutathione peroxidase (GPX), and glutathione (GSH) in hVFFs were significantly increased following treatment with tBHP and partially restored after coculture with TMSC. (e) qRT-PCR results showing that the HO1 mRNA level in TMSCs was upregulated upon tBHP treatment. No significant change in SOD1 and SOD2 transcript levels was observed. Results are 3 technical replicates of TMSC from one donor. Representative results from two different TMSCs with similar tendency were presented. For multigroup comparison, ANOVA followed by the Bonferroni post hoc test was used for statistics. 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Stem Cells International

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Figure 3

Figure 3: Antioxidant Properties of Tonsil-Derived Mesenchymal Stem Cells on Human Vocal Fold Fibroblast Exposed to Oxidative Stress 