Adipose-Derived Mesenchymal Stem Cells Modulate Fibrosis and Inflammation in the Peritoneal Fibrosis Model Developed in Uremic Rats

Figure 2

Histological features of peritoneal samples from the different groups stained with Masson’s trichrome (×200) (a). The quantification of these findings was demonstrated in bar graphs (b). There were no morphological alterations in the mesothelial, submesothelial, or muscle cells in the control and CKD groups. IP CG injections induced marked submesothelial peritoneal membrane thickening, characterized by increased cellularity and collagen deposition, as can be seen in the PF and CKD+PF groups. Animals submitted to CKD+PF which received ASC infusions exhibited preserved peritoneal membrane.

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