Mechanical Strain-Mediated Tenogenic Differentiation of Mesenchymal Stromal Cells Is Regulated through Epithelial Sodium Channels

Figure 3

Morphology of hMSCs after treatment with benzamil. (a) Morphological changes of hMSC cell culture after 72-hour incubation with benzamil. Increasing concentration of benzamil resulted in the appearance of small vesicles (probably apoptotic bodies, see arrow). (b) Morphology of the unstrained and strained cells at 1 Hz, 8%, at different durations of exposure to mechanical stretching, with or without administration of 10 μM benzamil, respectively.

(a)

(b)