Increased Expression of Sox9 during Balance of BMSCs/Chondrocyte Bricks in Platelet-Rich Plasma Promotes Construction of a Stable 3-D Chondrogenesis Microenvironment for BMSCs

Figure 4

A higher ratio of chondrocyte bricks prevents ossification of BMSCs at subcutaneous nonchondrogenic sites. Examining osteogenesis of grafts in vivo at 14 weeks. In contrast to the B2CB1 group (k‑n), the B1CB1 and B1CB2 groups did not present ossification of BMSCs through 14 weeks (a‑d, f‑i), as confirmed by Von-Kossa, Masson’s trichrome, COL-I, and COL-X immunostaining. , magnification ×100.