Transplantation of Stem Cells from Human Exfoliated Deciduous Teeth Decreases Cognitive Impairment from Chronic Cerebral Ischemia by Reducing Neuronal Apoptosis in Rats

Figure 3

SHED transplantation improved the cognitive function and production of neurons in rats with chronic cerebral ischemia (CCI). (a, b) In the Morris water maze (MWM) test, SHED transplantation by hippocampal infusion (, ) or by tail vein injection (, ) increased the spatial memory of CCI rats compared with that in the ischemia group. (c, d) Western blot analysis showed that the expression level of BDNF was markedly increased in the SHED-hippocampus group () and SHED-vein group () compared with that in the ischemia group. (e, f) Nissl staining showed that SHED transplantation increased the number of surviving neurons in the hippocampal CA1 region compared with that in the ischemia group. Error bars: . , . Scale bar: 50 μm.

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