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Patient | Before experimental therapy | After experimental therapy |
Epileptic seizure character | Drugs | EEG | Epileptic seizure character | EEG | Improvement |
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Patient 1 | Left sided generalizing, GTCS, polimorphic | VPA, CBZ, LEV, TPM (tacrolimus) | Simple changes, lateralized on the right side | Left sided, polimorphic | Simple changes, generalized and localized in the left fronto-central region | Transient reduction in number and severity of attacks |
Patient 2 | Left sided continuous | VPA, CBZ, PHT, OXC, (tacrolimus) | Frequent changes localized in right fronto-central region | Left sided continuous | Very frequent, bilateral changes localized in fronto-centro-pariertal region, more on the right | Mild reduction of gait disturbances |
Patient 3 | GTC, myoclonic | VPA, LEV, TPM, CBZ, (azathioprine) | Continuous changes localized predominantly in the left temporal and centro-parieto-occipital region | No seizures | Frequent changes localized predominantly in the left temporal and centro-parieto-occipital region | 100% improvement in functioning, lack of seizures |
Patient 4 | Polymorphic (atypical absences, GTCS, myoclonic) | VPA, PHT, CBZ, TPM, (azathioprine) | Frequent generalized and bilateral changes localized in the fronto-central region, more on the right side, hypsarrhythmia-like | Polymorphic (atypical absences, GTCS, myoclonic) | Very frequent generalized and bilateral changes localized in the fronto-central region, more on the right side, background slowing | Transient improvement after the first ADRC infusion |
Patient 5 | Focal with/without impartment of consciousness (GTCS) | VPA, CBZ, TPM, CLB | Frequent changes lateralized on the right side | Focal with/without impartment of consciousness, GTCS | Frequent changes lateralized on the right side | No |
Patient 6 | Focal with/without impartment of consciousness, GTCS | VPA, PB, LEV, TPM, VGB | Frequent changes localized in the left parasagittal region and simple changes localized in the fronto-central region on the right side | Focal with/without impartment of consciousness, GTCS | Frequent changes localized in the parasagittal region bilaterally more on the left side | 50% improvement in number and severity of attacks |
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