Pantoprazole (PPZ) Inhibits RANKL-Induced Osteoclast Formation and Function In Vitro and Prevents Lipopolysaccharide- (LPS-) Induced Inflammatory Calvarial Bone Loss In Vivo

<div>PPZ suppresses osteoclastogenesis by inhibiting the MAPK pathway and phosphorylation of Erk. (a) BMMs were cultured with M-CSF and RANKL, with or without PPZ (12.5 <i>μ</i>M) for 0, 1, 3, and 5 days. The cell lysates were probed for protein levels using western blot analysis. (b) PPZ treatment suppressed the expression of NFATc1. (c) PPZ treatment suppressed the expression of c-Fos. (d) BMMs were pretreated with 12.5 <i>μ</i>M PPZ for 1 h and then stimulated with RANKL for indicated times. The cell lysates were probed for protein levels using western blot analysis. (e) The expressions of pERK relative to total ERK was determined using ImageJ software. 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Stem Cells International

fig3

Figure 3

Figure 3: Pantoprazole (PPZ) Inhibits RANKL-Induced Osteoclast Formation and Function In Vitro and Prevents Lipopolysaccharide- (LPS-) Induced Inflammatory Calvarial Bone Loss In Vivo 

Figure 3 | Pantoprazole (PPZ) Inhibits RANKL-Induced Osteoclast Formation and Function In Vitro and Prevents Lipopolysaccharide- (LPS-) Induced Inflammatory Calvarial Bone Loss In Vivo 