Pantoprazole (PPZ) Inhibits RANKL-Induced Osteoclast Formation and Function In Vitro and Prevents Lipopolysaccharide- (LPS-) Induced Inflammatory Calvarial Bone Loss In Vivo

Figure 5

Histological and histomorphometric analysis of the effect of PPZ on LPS-induced bone loss in vivo. (a) Representative images of calvaria stained with H&E and TRAP from the sham group (PBS), LPS group (5 mg/kg bodyweight), LPS with low-dose PPZ group (2.5 mg/kg bodyweight), and LPS with high-dose PPZ group (10 mg/kg bodyweight). Black arrows indicate TRAP-positive cells. (b–d) Quantification of BV/TV of calvaria slice (%), TRAP-positive cell number, and TRAP-positive cell no./BS (). Data are presented as ; , relative to control.

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