The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration

<div>MSCs, injected 14 days after melanoma induction, promoted tumor growth by suppressing cytotoxicity of NK cells and by reducing antigen-presenting properties of tumor-infiltrating macrophages and DCs. Significantly lower number of granzyme B-expressing NK1.1+ cells (a), I-A-expressing and IL-12-producing F4/80+macrophages (b, c), and CD80- and I-A-expressing CD11c+DCs (d, e) were observed in the tumors of B16F10+MSC<sup>14d</sup>-treated mice compared to the B16F10+PBS<sup>14d</sup>-treated animals. 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Stem Cells International

fig3

Figure 3

Figure 3: The Effects of Mesenchymal Stem Cells on Antimelanoma Immunity Depend on the Timing of Their Administration 