Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System

<div>HIF-1<i>α</i> protein and mRNA expression in human islets cocultured with Hpc-MSCs and Nc-MSCs. (a) HIF-1<i>α</i> protein immunocytochemistry. (b) HIF-1<i>α</i> protein level in the islets expressed as graphs based on the H-score method. (c) HIF-1<i>α</i> gene expression in the islets. A comparison was done between the control and each cocultured islets (yellow arrows show positive protein expression). 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-12Z"></path></g><g transform="matrix(.013,0,0,-0.013,43.785,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.025,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>.</span> Nc-MSCs: normoxia condition mesenchymal stem cells; Hpc-MSCs: hypoxia preconditioning MSCs; D: direct coculture; I: indirect coculture.</div>

Stem Cells International

fig7

Figure 7

Figure 7: Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System 

Figure 7 | Hypoxia-Preconditioned Wharton’s Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System 