Bioengineering Approaches to Accelerate Clinical Translation of Stem Cell Therapies Treating Osteochondral Diseases
Figure 5
Synthetic gene circuits for self-regulated drug delivery systems. (a) IL-1 induced IL-1Ra expression through the NF-κB signaling pathway. (b) sTNFR1 inserted in CCL2 loci can be initiated by TNF and inhibit TNF in return. Reproduced with permission [67, 70].
