The Histone Demethylase KDM3B Promotes Osteo-/Odontogenic Differentiation, Cell Proliferation, and Migration Potential of Stem Cells from the Apical Papilla

Figure 3

KDM3B enhanced the migration and chemotaxis potential of SCAPs. The (a) scratch migration assay and (b) quantitative analysis results demonstrated that KDM3B knockdown led to a significant decrease in the migration ability of SCAPs at 24 h and 48 h. The (c) transwell chemotaxis assay and (d) quantitative analysis results showed that KDM3B knockdown led to a decrease in the chemotaxis ability of SCAPs at 24 h and 48 h. The (e) scratch migration assay and (f) quantitative analysis results demonstrated that KDM3B overexpression led to a significant increase in the migration ability of SCAPs at 24 h and 48 h. The (g) transwell chemotaxis assay and (h) quantitative analysis results showed that KDM3B overexpression led to an increase in the chemotaxis ability of SCAPs at 24 h and 48 h. Statistical significance was determined using Student’s -test. All error bars represent SD ( or 6). . .

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