Molecular Modulation of Fetal Liver Hematopoietic Stem Cell Mobilization into Fetal Bone Marrow in Mice

Figure 4

Adhesion molecules regulate fetal liver HSC mobilization into the fetal bone marrow. Increasing levels of MMP2, Robo4, L-selectin, VLA5, and N-cadherin in fetal bone marrow HSCs are involved in HSC mobilization from the fetal liver. Decreasing VE-cadherin expression in fetal HSCs favors HSC mobilization from the fetal liver.