Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors

Figure 1

Bone marrow MSC-Exo inhibit CML cell proliferation in vitro. (a) Transmission electron microphotographs of exosomes isolated from bone marrow MSC. The scale bars indicate 100 nm. (b) Detection of CD63, TSG101, and CD81 expression in MSC-Exo by western blotting. (c) Cell proliferation of K562 and PCML cells cocultured with different concentrations of hBMMSC-Exo (0, 50, 100, 150, and 200 μg/mL). The data were expressed as the of the three independent experiments. Student’s -test.

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