Medications for Hypertension Change the Secretome Profile from Marrow Stromal Cells and Peripheral Blood Monocytes

Figure 1

Antihypertensive medications alter the secretome of monocytes from healthy controls and stroke patients after 24 hours of exposure. Atenolol (a–d) increased IL-1RA and TNF-α secretions from stroke patient-derived monocytes but reduced the IL-1RA and MCP-1 secretions from health control monocytes. Captopril (e–h) increased IL-1RA secretions from stroke patient-derived monocytes but increased IL-8 secretions from both healthy control and stroke monocytes. Losartan (i–l) did not alter cytokine secretions from stroke patient-derived monocytes but reduced MCP-1 secretions from healthy control monocytes. Significance is shown by . All fold changes are as compared to vehicle control.

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