Review Article

Evaluation of the Efficacy of Stem Cell Therapy in Ovariectomized Osteoporotic Rats Based on Micro-CT and Dual-Energy X-Ray Absorptiometry: A Systematic Review and Meta-Analysis

Table 1

Characteristics of all studies included in the meta-analysis.

StudyCountryStudy typeAnimal modelsAge and weightNo. of ratsOsteoporosis modelExperimental groupInjection doseControl groupDetection timeDetection sitesOutcome measures

Uejima et al. (2008)JapanNon-RCTSD, female, rats12 w10/10OVXBMSCs

Sham-operation+saline8 w
24 w
24 w
Femur(1)
Yang et al. (2013)ChinaRCTSD, female, rats10/10/10OVXBMSCsOVX control, sham-operation12 wFemur, lumbar vertebrae(1)
Shuai et al. (2014)ChinaRCTSD, female, rats140-150 g4/4/4OVXBMSCs
OVX control, sham-operation+PBS10 w
10 w
Femur(1), (3)
Lei et al. (2016)ChinaRCTWistar, female, rats210-255 g15/15/45OVXAM-MSCs+zoledronic acidNPOVX control, sham-operation13 wFemur(1)
Li et al. (2016)ChinaRCTSD, female, rats7 w, 180-220 g10/10/10OVXADSCsOVX control, sham-operation+PBS6 wFemur(1), (2)
Chen et al. (2017)ChinaRCTSD, female, rats7 w, 180-220 g10/10/10OVXBMSCsOVX control, sham-operation+PBS2 wFemur, lumbar vertebrae(1), (2), (3)
Duan et al. (2017)ChinaRCTSD, female, rats10 w, 18/10OVXBMSCsOVX control, sham-operation8 wTibia(2), (3)
Hong et al. (2018)South KoreaRCTSD, female, rats12 w10/10/10OVXhUCB-MSCs
OVX control, sham-operation4 w
8 w
Femur(3)
Tang et al. (2018)ChinaRCTSD, female, rats3 m, 10/10/10OVXADSCs+icariinNPOVX control, sham-operation12 wFemur, lumbar vertebrae(1)
Uri et al. (2018)IsraelRCTSD, female, rats5 m, 15/15OVXADSCsNPOVX controlNPFemur(3)
Xue et al. (2019)ChinaRCTSD, female, rats30/10/10OVXBMSCs

OVX control, sham-operation4 w, 8 w
4 w, 8 w
4 w, 8 w
Tibia(1)
Sadat-Ali et al. (2019)Saudi ArabiaNon-RCTSD, female, ratsNP10/10OVXBMSCsOVX control+saline8 wFemur(2), (3)
Aglan et al. (2020)EgyptNon-RCTWistar, female, rats130-150 g30/10/10OVXBMSCs+nano-HA
BMSCs+Pt-NPs
BMSCs+Pt-HA-nanocomposite
OVX control, sham-operation2 mFemur(1)

RCT: randomized controlled trial; SD: Sprague Dawley; OVX: ovariectomized; BMSCs: bone marrow mesenchymal stem cells; ADSCs: adipose-derived stem cells; AM-MSCs: amniotic membrane mesenchymal stem cells; hUCB-MSCs: human umbilical cord blood-derived mesenchymal stem cells; PBS: phosphate-buffered saline; NP: not provided. Outcome measures: (1): BMD; (2): BV/TV; (3): Tb.N, Tb.Th, and Tb.Sp. Detection time: from after stem cell injection.