Review Article
Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
Table 1
Gene therapy for natural healing of the tendon.
| Genes | Delivery method | Function | Reference |
| Tnmd | Transfection | Major constituents of collagen fiber. Positively regulated by Scx | [47] | Scx | Polymersome scaffolding material | Major marker of tendon & ligament tissues. Encode protein which expressed during embryonic development | [13] | Fmod | Carried by fibrin gel | Positively regulate expression of TGF-β. Encode protein which play role in ECM deposition | [47] | COL-I | Transfection | Major constituents of ECM | [162] | COL-III | Transfection | Major constituents of ECM | [162] | COL-V | Transfection | Constituent of ECM and play role in fiber strength | [163] | LAMA-4 | Fibrin-heparin-based delivery | Encodes laminin alpha-4, noncollagenous constituent of ECM | [164] | ELN | Liposomal nanoparticles | Encodes elastin protein, major structural constituent of ECM | [164] | FBN-II | Carried by fibrin gel | Encodes fibrillin-II protein, major structural constituent of ECM | [164] | Comp | Nanoliposomes | Belongs to the ECM protein. Structural role | [165] | Decorin | PLGA-NP | Constituent of ECM structural protein, positively regulated by TGF-β, and enhance strength and organization of collagen fibers | [160] |
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Abbreviations: Tnmd: tenomodulin; Scx: scleraxis; Fmod: fibromodulin; COL-I: collagen-I; LAMA-4: laminin subunit alpha-4; ELN: elastin gene; FBN-II: fibrillin-II; Comp: cartilage oligomeric matric protein.
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