Review Article
Tendon Tissue Repair in Prospective of Drug Delivery, Regenerative Medicines, and Innovative Bioscaffolds
Table 3
Recent cell-based approach for tendon regeneration.
| Cell line | Study type | Tendon model | Results | Reference |
| Tenocytes | Rabbit Achilles tendon | In vivo | Increased ECM production and enhanced orientation of collagen fibers | [82] | ADSC | Rabbit Achilles tendon | In vitro/in vivo | Production of tendon fibers with better (60%) tensile strength | [128] | Dermal fibroblast | Human patella refractory tendinopathy | Clinical trial | Increased tendon thickness, reduction in pain and enhanced mechanical strength | [131] | BM-MSC | Equine tendon model | In vitro/in vivo | Improved histological parameters, increased orientation of collagen fibers and decrease in cellularity | [141] | Muscle-derived stem cells | Muscle muscularis fascia of dorsum | In vivo | Enhanced stiffness, tensile strength and improved cross linking of collagen fibers | [90] | Periosteal progenitor cells | Rabbit infraspinatus tendon model | In vivo | Increased content of col-I & COL-II and enhanced ECM production | [128] | Tendon stem cells | Rat patella tendon model | In vitro/in vivo | Increased collagen fiber thickness, ECM deposition and production of col-I, II and Tnmd | [93] |
|
|
Abbreviations: ADSC: adipose-derived stem cells; BM-MSC: bone marrow-derived mesenchymal stem cells.
|