Research Article
Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1
Figure 4
MiR-146a-5p is the potential target of MSCs-Exo in sepsis. (a) The comparative toxicogenomics database and GeneCards database were used to identify the potential target of MSCs-Exo. (b) The profiler cluster analysis was employed to select gene with higher expression from the selected target genes with transcriptional activity. (c) The expression levels of the top five miRNAs (miR-146a-5p, miR-125a-5p, miR-34a-5p, miR-29b-3p, and miR-21-5p) in sepsis model were detected by RT-qPCR. vs. the control group.
(a) |
(b) |
(c) |