Exosomes Derived from miR-146a-5p-Enriched Mesenchymal Stem Cells Protect the Cardiomyocytes and Myocardial Tissues in the Polymicrobial Sepsis through Regulating MYBL1

Figure 7

MYBL1 was the target of miR-146a-5p. (a) The Mirdb, Targetscan, and RNA-Society databases were employed to identify the target of miR-146a-5p. (b) Five potential target (MYBL1, HNRPD, ZNF637, NUCKS1, and ZNF652) of miR-146a-5p were screened by profiler cluster analysis. (c) The expression levels of MYBL1, HNRPD, ZNF637, NUCKS1, and ZNF652 in sepsis model were detected by RT-qPCR. , , vs. the control group. (d) The predicted miR-146a-5p binding sites in the region of MYBL1 and the corresponding mutant sequence were shown. (e) The relative values of luciferase signal. (f) The relative expression of MYBL1 in LPS-induced H9C2 cells after transfected with NC mimics and miR-146-5p mimics, respectively. (g) The protein expression of MYBL1 in LPS-induced H9C2 cells after transfected with NC mimics and miR-146-5p mimics, respectively. vs. the NC mimics.

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