Transposable Element Dynamics and Regulation during Zygotic Genome Activation in Mammalian Embryos and Embryonic Stem Cell Model Systems

Figure 1

Schematic representations of key TE classes present in mammalian genomes. TEs can be broadly classified into DNA transposons (class II) and retrotransposons (class I). For a specific breakdown of each order, please refer to the review by [6]. Abbreviations: GAG: capsid protein; ENV: envelope protein; POL: coding region that encodes one or more of the following: proteinase, reverse transcriptase, RNaseH, polymerase, or integrase; TIR: terminal inverted repeat; LTR: long-terminal repeat; UTR: untranslated regions; EN: endonuclease; RT: reverse transcriptase; A and B: RNA polymerase III promoter box.