Adipose Mesenchymal Stem Cell-Derived Exosomes Enhance PC12 Cell Function through the Activation of the PI3K/AKT Pathway

<div>Inhibition of the PI3K/AKT signaling pathway could influence the biological behaviors of PC12 cells. (a) CCK-8 assay. The addition of LY294002 could inhibit the proliferation of PC12 cells treated with ADSC-exo (100 <i>μ</i>g/ml). (b, d) Transwell migration assay. LY294002 could decrease the cell migration promoted by ADSC-exo (100 <i>μ</i>g/ml) in PC12 cells. (c, e) Flow cytometry assay. The antiapoptotic effects of ADSC-exo (100 <i>μ</i>g/ml) were reversed after suppressing the Wnt/<i>β</i>-catenin signaling pathway by LY294002. 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Stem Cells International

fig7

Figure 7

Figure 7: Adipose Mesenchymal Stem Cell-Derived Exosomes Enhance PC12 Cell Function through the Activation of the PI3K/AKT Pathway 