Review Article
Cloning and Embryo Splitting in Mammalians: Brief History, Methods, and Achievements
Table 5
Recent studies in embryo splitting.
| Species | Embryo sample | Method | Results | Reference |
| Human | 4-cell | Biopsy | NANOG expression in TE & ICM | [59] | Mouse | 2-cell | Biopsy | Oct4 expression in blastocysts | [67] | Mouse | 2-cell | Biopsy | Sox2 expression in blastocysts | [68] | Mouse | 2-cell | Biopsy | Cdx2 expression in blastocysts | [69] | Mouse | 2-cell | Biopsy | NANOG expression in blastocysts | [70] | Mouse | 2-cell | Biopsy | 100% Arntl and 91% Prrt2 knockout by C-CRISPR | [65] | Cynomolgus monkeys | Cynomolgus monkeys | 2-cell | Biopsy | Dax1 knockout by CRISPR/Cas9 | [71] | Rhesus monkey | 4-cell | Biopsy | Dystrophin gene knockout by CRISPR/Cas9 | [72] |
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