Stem Cells International

Review Article

FGF2 and EGF for the Regeneration of Tympanic Membrane: A Systematic Review

Table 3

Summary of FGF2 and EGF effects on human chronic perforation.
AuthorsStudy objectEtiologyStudy designSize of perforationFollow-up (months)Treatment strategyClosure rateClosure time (weeks)
FGF2 groupControl groupFGF2 groupControl groupFGF2 groupControl groupFGF2 groupControl group
Hakuba et al. [47] (2003)14 adultCOMControl study16.5%9.6%3FAS for 2 weeksSAS for 2 weeks100% (9/9)40% (2/5)3.7 (2-6)3.6 (2-4)
Hakuba et al. [48] (2010)87 adult60 COM:7 VT:20 traumaObservation study14.4%3FAS for 3 weeks92.0% (80/87)4.8
Kanemaru et al. [49] (2011)63 adultCOMRandomized control trial.3FGF via GF for 3 weeksSaline via GF98.1% (52/53)10.0% (1/10)41 (78.8%) within 312
Hakuba et al. [50] (2013)116 adult77 COM:12 trauma:15 VTObservation study12FAS for 3 weeks62% (73/116)Unclear
Acharya et al. [51] (2015)12 childrenVT or COMProspective cohort study6-40%12FGF via Gel for 3 weeks58% (7/12)2-12
Hakuba et al. [52] (2015)153 adultCOMRetrospective cohort study12FAS for 3 weeks66.0% (101/153)4.5
Omae et al. [53] (2017)10 adult5 COM:traumaProspective clinical trial3FGF via Gel for 4 weeks88.9% (8/9)57 days
Santos et al. [54] (2020)54 adultTrauma, COM, and unknownRandomized controlled trial82.4%753FGF via Gel for 3 weeksSGF for 3 weeks57.5%(23/40)71.4% (10/14)14 in one, 8 in 2, and 1 in 34 in one, 5 in 2, and 1 in 3
Ramsay et al. [55] (1995)17 adult1 traumatic and 16 COMDouble-blind randomized control trialUnclearUnclear2.6EGF via paperPBS+paper0/8, size of perforation mean decrease 0.3%1/9, 2.7%
FAS: bFGF via atelocollagen and sealed by silicon layer; SAS: saline via atelocollagen and sealed by silicon layer; FGF: FGF-2 via gelatin sponge and sealed by fibrin glue; GF: gelatin sponge and fibrin glue. COM: chronic otitis media; VT: ventilation tube; Gel: gelatin sponge.