Comparing the Therapeutic Potential of Stem Cells and their Secretory Products in Regenerative Medicine

Figure 6

Preconditioning approaches to enhance the secretion and therapeutic efficacy of exosomes. The yield of secretome can be increased by preconditioning strategies such as introducing hypoxic and serum deprivation culture conditions and genetic modification using CRISPR technology as well as overexpression of certain genes. LPS: lipopolysaccharides; NO: nitric oxide; IL: interleukin; miRNAs: micro RNAs; UV: ultraviolet (created with BioRender.com).