Comparing the Therapeutic Potential of Stem Cells and their Secretory Products in Regenerative Medicine

Table 1

Recent studies applied secretome and its components via intravenous (IV) route.

Cell type	Disease model	Application method	References
Cardiac stem cells	Cardiac myopathy	IV injection of 30×10^9 exosomes	[122]
BMSCs	Pulmonary hypertension	IV injection of culture media (30 μg/100 μL)	[123]
BMSCs	Asthma	IV injection of culture media (500 μg/mL)	[124]
BMSCs	Lung fibrosis	IV injection of 10 μg EVs	[125]
MSCs	Myocardial inflammation	IV injection of 200 μL of 300 μg exosomes	[126]
iPSCs	Limb ischemia	IV injection of 200 μg exosomes	[127]
hMSC544 cells	Ovarian cancer	IV injection of 100 μL exosomes	[128]
Schwann cells	Peripheral neuropathy caused by type 2 diabetic	IV injection of 200 μL exosomes	[129]
BMSCs	COVID-19	IV injection of 15 mL exosomes	[130]