Review Article

Comparing the Therapeutic Potential of Stem Cells and their Secretory Products in Regenerative Medicine

Table 5

Genetic modifications in human MSCs and the disease models tested.

Factor overexpressedMSC sourceMethodDiseaseReference

AktHuman umbilical cordAdenovirusAcute myocardial infarction[187]
Angiotensin II type 2 receptorHuman bone marrowLentivirusLPS-induced acute lung injury[188]
Arginine decarboxylaseHuman adipose tissueRetrovirusSpinal cord injury[189]
Basic fibroblast growth factor (bFGF)Human bone marrowLentivirusAngiogenesis[190]
Brain-derived neurotrophic factor (BDNF)Human umbilical cord bloodPlasmid transfectionNeurological injury and disease[191]
Human bone marrowLentivirusNeuronal degeneration[192]
C-C chemokine receptor type 2 (CCR2)Human bone marrowLentivirusIschemic stroke[193]
CXC chemokine receptor 4 (CXCR4)Human umbilical cordLentivirusRadiation- induced lung injury[194]
Cytosine deaminase (CD) and herpes simplex virus thymidine kinase (HSV-tk)Human umbilical cord bloodLentivirusOvarian cancer[195]
Ephrin-B2Human bone marrowPlasmid transfectionIschemic tissues[196]
Forkhead box protein (Foxa2)Human adipose tissuePlasmid transfectionAcute liver injury[197]
Glial-derived neurotrophic factor (GDNF)Human adiposeLentivirusRenal interstitial fibrosis[198]
Human bone marrowAdenovirusNephrotoxic serum nephritis[199]
Glucocorticoid-induced tumour necrosis factor-related receptor (GITR)Human bone marrowPlasmid transfectionSmall cell lung cancer[200]
Granulocyte chemotactic protein-2 (GCP-2)Human adipose tissueLentivirusMyocardial infarction[201]
Heme oxygenase-1 (HO-1)Human embryonic stem cellLentivirusMyocardial infarction[202]
Hepatocyte growth factor (HGF)Human bone marrowRetrovirusBladder outlet obstruction[203]
Human umbilical cordLentivirusMyocardial infarction[204]
Human bone marrowAdenovirusLiver fibrosis[205]
Human umbilical cordAdenovirusInjured sinonasal mucosa[206]
Human umbilical cordAdenovirusParkinson’s disease[207]
Human umbilical cord bloodPlasmid transfectionLiver fibrosis[208]
Human bone marrowLentivirusSpinal cord injury[209]
Hepatocyte nuclear factor 4a (HNF 4a)Human umbilical cordLentivirusHepatocellular carcinogenesis[210]
Human N-cadherinHuman umbilical cord bloodLentivirusMyocardial infarction[211]
Hypoxia inducible factor-1a (HIF-1a)Human bone marrowLentivirusAngiogenesis[212]
IL-4Human adipose tissueLentivirusMultiple sclerosis[213]
IL-10Human amniotic fluidHuman amniotic fluidLiver fibrosis[214]
Human bone marrowAAVAcute ischemic stroke[215]
LeptinHuman bone marrowLentivirusMyocardial infarction[216]
LIM-homeobox transcription factor islet-1 (ISL1)Human bone marrowLentivirusMyocardial infarction[217]
miR-101-3pHuman bone marrowLentivirusOral cancer[217]
miR-16-5pHuman bone marrowPlasmid transfectionColorectal cancer[218]
miR-199aHuman bone marrowPlasmid transfectionGlioma[218]
miR-199a-3pHuman bone marrowmiRNA transfectionRenal ischemia/reperfusion injury[219]
miR-let-7d or miR-154Human bone marrowLentivirusLung injury[220]
miRNA-181Human umbilical cord bloodLentivirusMyocardial ischemia-reperfusion injury[221]
Neuregulin 1 (NRG1)Human adipose tissueAdenovirusCerebral ischemia[222]
Nuclear factor (erythroid-derived 2)-like 2 (Nrf2)Human amniotic fluidLentivirusAcute lung injury[194]
Oct4 and Sox2Human adipose tissuePlasmid transfectionLiver injury[223]
PARKINHuman Wharton’s jellyPlasmid transfectionParkinson’s disease[224]
Pigment epithelial-derived factor (PEDF)Human bone marrowLentivirusHepatocellular carcinoma[225]
SRC3-specific short hairpin RNA (sh-SRC3)Human bone marrowLentivirusMultiple myeloma[226]
sST2Human adipose tissueLentivirusOccupational asthma[227]
Human adipose tissueLentivirusEndotoxin-induced acute lung injury[228]
Thioredoxin-1 (Trx-1)Human umbilical cordAdenovirusAcute radiation injury[229]
Tissue matrix metalloproteinase inhibitor 2 (TIMP2)Human umbilical cordLentivirusMyocardial infarction[230]
TNF-related apoptosis-inducing ligand (TRAIL)Human bone marrowLentivirusNon-small-cell lung cancer[231]
Human adipose tissuePlasmid transfectionNon-small-cell lung cancer[232]
Human adipose tissueLentivirusGlioblastoma multiforme[233]
Transforming growth factor b1 (TGF-b1)Human bone marrowLentivirusAngiogenesis[190]
Vascular endothelial growth factor (VEGF)Human bone marrowLentivirusPeripheral nerve injury[234]