Comparing the Therapeutic Potential of Stem Cells and their Secretory Products in Regenerative Medicine

Table 6

Tissue engineering therapies using MSCs.

Disease	Study organism	Cell	Scaffold	Outcome	Reference
Osteochondral defect	Rabbit	Autologous MSCs	Injectable synthetic ECM	Cartilage filled the full-thickness defect	[242]
Spinal cord injury	Rat	Autologous MSCs	Hydrogels	Enhanced ingrowth of axons in the lesion and improvement in function	[243]
Critical size bone defect	Mouse	OSX-modified murine MSCs	Collagen sponge	Enhanced bone formation	[244]
Tendon defect	Rat	C3H10T1/2 cells stably transfected with BMP-2 and active Smad8 variant	Collagen sponge	Tendon regeneration	[245]
Articular cartilage defect	Rabbit	Autologous MSCs modified with TGF-1	Chitosan scaffold	Enhanced repair; defect filled with hyaline cartilage	[246]