A Novel High-Content Screening-Based Method for Anti-<i>Trypanosoma cruzi</i> Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

<div>NT-pro-BNP analysis and correlations with morphology parameters. (a) NT-pro-BNP levels in the culture supernatant 48 h following treatment with the compounds in different concentrations. Dash lines represent NT-pro-BNP levels in the culture supernatant of untreated hiPSC-CMs (black) 48 h following treatment with endothelin-1 (orange). (b) Correlation matrix heat map demonstrating <svg height="8.8423pt" id="M37" style="vertical-align:-0.2064009pt" version="1.1" viewbox="-0.0498162 -8.6359 8.28119 8.8423" width="8.28119pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M610 18C585 26 567 34 540 68C517 97 499 128 476 171C452 215 425 276 413 304C496 332 570 394 570 494C570 555 545 595 509 619S419 650 364 650H139L133 622C216 615 219 612 203 527L129 132C112 40 105 36 23 28L17 0H279L285 28C199 34 194 40 211 132L239 284H284C320 284 334 275 351 236C374 182 394 140 420 93C459 23 495 -1 592 -8H600L610 18ZM480 485C480 424 449 372 403 342C374 323 338 316 293 316H245L291 562C296 589 301 601 311 608S337 618 358 618C432 618 480 575 480 485Z"></path></g></svg> values found for each comparison between the different variables.</div>

Stem Cells International

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Figure 5

Figure 5: A Novel High-Content Screening-Based Method for Anti-<i>Trypanosoma cruzi</i> Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes 

Figure 5 | A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes 