Research Article

A Novel High-Content Screening-Based Method for Anti-Trypanosoma cruzi Drug Discovery Using Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Table 1

Cytotoxicity against hiPSC-CMs and anti-T. cruzi activity against intracellular amastigotes.

CompoundCC50 (μM)EC50 (μM)SI

BA512
GT5A46
GT5B33
Benznidazole>100>17

CC50: cytotoxicity concentration 50%; EC50: effective concentration at 50% inhibitory concentration for inhibition of T. cruzi amastigotes. Values are of three independent experiments.