Curcumin and Mesenchymal Stem Cells Ameliorate Ankle, Testis, and Ovary Deleterious Histological Changes in Arthritic Rats via Suppression of Oxidative Stress and Inflammation

Figure 9

Photomicrographs of rat testis sections. (a) From the RA group showing capillary congestion (C), hemorrhage (H), and focal necrosis in germinal cells (FN). (b) From the RA group showing pyknotic nuclei (thin arrows) of primary spermatocytes (PS), interstitial edema (star), and degeneration of germ cells (DG). (c) From the RA group showing irregular variable-sized seminiferous tubules and atrophy in seminiferous tubules, with most tubules showing a marked decrease in the number of spermatogenic cells; consequently, the lumen of the tubules appeared with few or no sperms observed. (d–f) From arthritic-treated groups with curcumin, stem cells, and a mixture of stem cells and curcumin, respectively, showing a nearly normal histological structure of the seminiferous tubules (H&E).

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