Spatial-Temporal Patterns and Inflammatory Factors of Bone Matrix Remodeling

Figure 3

The quaternary hierarchical architecture of collagen and mineral assembly. The first structure is collagen molecules with the triple helix [15]. Secondly, collagen molecules form microfibrils with -bands, and ACP embraces outside of microfibrils [54, 55]. Then, HA crystals nucleate the gap regions within mineralized collagen fibrils [55]. Finally, mineralized collagen fibers with mineral crystals create an intercalated cross-fibrillar network [59].