CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway

<div>circFAT1 silencing inhibits osteoblastic differentiation potential of PDLSCs. (a)–(c) Western blot and RT-qPCR showed that osteogenic markers (RUNX2, OSX, COL1A, and COL3A) were downregulated in the circFAT1 siRNA-treated PDLSCs (si-FAT1 group). (d, e) Silence of circFAT1 reduced the ALP activity of PDLSCs 7 days after osteogenic induction. ARS showed the mineralization of PDLSCs was decreased significantly in the si-FAT1 group after osteogenic induction for 14 days. 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Stem Cells International

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Figure 3

Figure 3: CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway 