Single-Cell Transcriptome Analysis of Human Adipose-Derived Stromal Cells Identifies a Contractile Cell Subpopulation

Table 1

Statistically significant () DEGs identified in cluster 1 that encode for proteins that play a role in contractile cells.

Genes	Protein	Function	References
ACTA2	Alpha smooth muscle actin (α-SMA)	Involved in vascular contractibility and blood pressure homeostasis.	[15, 27–31]
COL11A1	Collagen alpha-1(XI) chain	One of three chains that make up type XI collagen.	[26, 28]
SYNPO2	Myopodin or synaptopodin-2	Nonmotor actin binding protein that interacts with α-SMA.	[28]
CALD1	Caldesmon (heavy and light chain)	Cytoskeletal protein that interacts with actin, tropomyosin, myosin, calmodulin, and phospholipids.	[28, 30–32]
TAGLN	Transgelin (SM22-α)	Nonmotor actin binding protein.	[27, 28, 31, 33]
MYLK	Myosin light chain kinase	Calcium/calmodulin dependent enzyme that phosphorylates myosin regulatory light chains.	[28, 34]
MYL12A	Myosin regulatory light chain 12A	Regulates smooth muscle contraction.	[28, 35]
TPM2	Beta-tropomyosin	Controls the binding of myosin and actin.	[28, 34]