Research Article

Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway

Figure 8

Schematic diagram shows the potential mechanism of physiological hydrostatic pressure effects the IVD cell survival and ECM homeostasis: low-loading physiological hydrostatic pressure activates mechanosensitive factors N-CDH and integrin β1, which inhibit Hippo-YAP/TAZ pathway-mediated cell apoptosis and ECM catabolism.