Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway

<div>Schematic diagram shows the potential mechanism of physiological hydrostatic pressure effects the IVD cell survival and ECM homeostasis: low-loading physiological hydrostatic pressure activates mechanosensitive factors N-CDH and integrin <i>β</i>1, which inhibit Hippo-YAP/TAZ pathway-mediated cell apoptosis and ECM catabolism.</div>

Stem Cells International

fig8

Figure 8

Figure 8: Hydrostatic Pressure Modulates Intervertebral Disc Cell Survival and Extracellular Matrix Homeostasis via Regulating Hippo-YAP/TAZ Pathway 