Research Article

Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway

Figure 2

The influence of metformin treatment on DPSC proliferation. (a) The influence of metformin on young and (b) aging DPSC proliferation. Young and aging DPSCs were treated with 10, 50, 100, 250, and 500 μM metformin for 1 to 10 days; cells with no drug added (0 μM) served as controls. Cell proliferation was determined by CCK-8 assay. The absorbance value was read at a wavelength of 450 nm. a, , 100 μM versus 0 μM; b, , 100 μM versus 0 μM; c, , 500 μM versus 0 μM; d, , 500 μM versus 0 μM; e, , 250 μM versus 0 μM.
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