Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway

<div>Metformin inhibits senescence in DPSCs. Young and aging DPSCs were treated with 100 <i>μ</i>M metformin for 48 h. (a) Cellular senescence was determined using SA-<i>β</i>-gal staining. Representative images are shown (scale bar: 20 <i>μ</i>m). (b) Quantitative analysis of SA-<i>β</i>-gal-positive cells. (c) Representative blots of p53, p21, and p16 protein expression levels by western blotting. (d) Quantitative analysis of p53, p21, and p16 proteins. 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Stem Cells International

fig3

Figure 3

Figure 3: Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway 

Figure 3 | Metformin-Induced MicroRNA-34a-3p Downregulation Alleviates Senescence in Human Dental Pulp Stem Cells by Targeting CAB39 through the AMPK/mTOR Signaling Pathway 