Inhibition of Endoplasmic Reticulum Stress by 4-Phenyl Butyric Acid Presents Therapeutic Effects on Periodontitis: Experimental Studies In Vitro and in Rats

Figure 1

4-PBA reverses ER stress in PDLSCs under inflammatory periodontitis condition. RT-qPCR showed (a) the expression levels of UPR representative genes GRP78, PERK, ATF4, and CHOP in P-PDLSCs treated with or without 5 mM 4-PBA for 7 days; (b) the expression levels of UPR representative genes were measured in H-PDLSCs treated in the absence or presence of 10 mg/l LPS or LPS in association with 5 mM 4-PBA for 7 days. The consequences were normalized to the GAPDH gene, and data represent (). , , .

(a)

(b)