Inhibition of Endoplasmic Reticulum Stress by 4-Phenyl Butyric Acid Presents Therapeutic Effects on Periodontitis: Experimental Studies In Vitro and in Rats

Figure 3

4-PBA restores the impaired osteogenic differentiation ability of PDLSCs in the inflammatory microenvironment. The mRNA and protein expression levels of Runx2 and OCN were determined by RT-qPCR after one week (a, b) and Western blot analysist after 14 days (c–f). P-PDLSCs were treated with or without 5 mM 4-PBA, and H-PDLSCs treated in the absence or presence of 10 mg/l LPS or LPS in association with 5 mM 4-PBA. The consequences were normalized to the GAPDH gene, and data represent (). , , .

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