Inhibition of Endoplasmic Reticulum Stress by 4-Phenyl Butyric Acid Presents Therapeutic Effects on Periodontitis: Experimental Studies In Vitro and in Rats

Figure 5

Local administration of 4-PBA rescues alveolar bone resorption in an LPS-induced periodontitis rat model. (a) Micro-CT acquired the representative images of the alveolar bone loss. (b) Alveolar bone resorption analysis of maxillary molars. Six sites for three molars were analyzed morphometrically (one site for each root of one tooth). The distance between the cement-enamel junction (CEJ) and alveolar crest of the mesial and distal roots of the three maxillary molars was assessed under a stereoscopic microscope. The results indicated more alveolar bone loss in the LPS (10 μg/day) treated groups compared to the saline group (10 μl). Local administration of 4-PBA (5 nmol/day) rescued the bone resorption induced by LPS. The data represent (). , , .

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