Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy

<div>Rapamycin reduces the inflammatory/catabolic response in rat PTSCs. (a) qRT-PCR shows that rapamycin decreases the MMP-13 expression that was upregulated by bleomycin. (b) No significant difference was observed on the IL-6 expression when cells were treated with bleomycin alone, or a combination with rapamycin. (c) Rapamycin decreases the bleomycin-induced TNF-<i>α</i> expression. 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Cont: control; Bleo: bleomycin; Rapa: rapamycin.</div>

Stem Cells International

fig5

Figure 5

Figure 5: Rapamycin Treatment of Tendon Stem/Progenitor Cells Reduces Cellular Senescence by Upregulating Autophagy 