Extracellular Vesicles: Novel Roles in Neurological Disorders

Figure 4

Exosomes act as natural vesicles or drug delivery tools to treat neurological disorders. Exosomes can carry their own substances or therapeutic exogenous cargoes through BBB into the damaged sites of CNS, with low toxicity and immunogenicity. CNS: central nervous system; BBB: blood-brain barrier; SCI: spinal cord injury; AD: Alzheimer’s disease; PD: Parkinson’s disease; IDE: insulin-degrading enzyme; HSP: heat shock protein; PTEN: phosphatase and tensin homolog; BACE1: beta-secretase 1.