miR-375 Promotes Pancreatic Differentiation In Vitro by Affecting Different Target Genes at Different Stages

Figure 4

Overall description of 272 possible miR-375 target genes for the four differentiation stages in control vs. OE and control vs. IE. (a) Heatmap showing the expression levels of 272 possible miR-375 target genes in the four differentiation stages in the OE, IE, and control groups. Hierarchical clustering of gene expression patterns was performed, and its expression level was standardized to TPM (transcripts per kilobase of exon model per million mapped reads). (b) Dot plot showing the KEGG enrichment pathways of 272 possible target genes. The abscissa represents the gene enrichment ratio, the bubble size represents the number of enriched genes in this pathway, and the color represents the value (adjusted value). (c) Trend analysis of target gene expression (10 trends) by STEM (Short Time-series Expression Miner). Colored blocks: significantly enriched trend ().

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