Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells

Figure 4

Proliferation and apoptosis of HCECs in damage conditions, treated with different doses of MSC-EVs. (a). Proliferation levels of HCECs maintained in 2% FBS for 24 hours and treated for further 24 hours with different doses of MSC-EVs ( MSC-EV/cell). Data are represented as of four independent experiments normalized to CTL. (b). Percentage of early apoptotic (black columns) and late apoptotic (grey column) HCECs cultured either in ENDOGRO 10% (CTL) or in 2% FBS for 24 hours (2%) and treated for further 24 hours with different doses of MSC-EVs (10 and MSC-EV/cell). One-way ANOVA analysis with Tukey’s multicomparison test was performed among 2% FBS alone and (, ).

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