Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells

<div>Wound healing assay of HCECs in damage conditions treated with MSC-EVs. (a) Wound healing assays were performed to evaluate cell motility of the HCECs in damage conditions (2% FBS); the migration rate was measured by the length of the scratch at different timings (T0 and T6), in absence (T6 2%) or in presence of <svg height="11.9413pt" id="M25" style="vertical-align:-0.3499002pt" version="1.1" viewbox="-0.0498162 -11.5914 43.5702 11.9413" width="43.5702pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 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One-way ANOVA analysis with Tukey’s multicomparison test was performed among 2% FBS and <svg height="8.99234pt" id="M28" style="vertical-align:-0.4673605pt" version="1.1" viewbox="-0.0498162 -8.52498 50.9157 8.99234" width="50.9157pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z"></path></g><g transform="matrix(.013,0,0,-0.013,6.24,0)"><path d="M594 629L561 652L159 -9L190 -32L594 629ZM194 635C92 635 49 534 49 453C49 374 92 272 193 272C295 272 338 374 338 454S295 635 194 635ZM193 605C257 605 265 504 265 453C265 405 257 302 194 302C133 302 122 403 122 454S133 605 193 605ZM567 351C465 351 421 250 421 169C421 90 465 -12 566 -12S710 90 710 170S667 351 567 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Stem Cells International

fig5

Figure 5

Figure 5: Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells 