Effect of Stem Cell-Derived Extracellular Vesicles on Damaged Human Corneal Endothelial Cells

Table 1

Clinical and biological information of patients undergoing penetrating keratoplasty. In the table are listed the clinical and biological aspects of patients from which we received corneal buttons.

Sex	Age	Diagnosis	Surgical procedure	Medical history	Ophthalmological therapy
F	75	Ocular hypertonia of traumatic etiology	Enucleation	Allergies (indomethacin, tramadol, ciprofloxacin), arterial hypertension	Topical therapy: timolol, diclofenac
F	35	Keratoconus	PKP		Topical therapy: hydrocortisone
F	66	Fuchs’ endothelial corneal dystrophy (FECD)	PKP	Smoking, diabetes mellitus type II, arterial hypertension	Topical therapy: loteprednol (od)
F	47	Corneal leukoma	PKP	Postsurgical hypothyroidism
M	75	Corneal leukoma	PKP	Arterial hypertension, benign prostatic hypertrophy	Systemic therapy: acetazolamide; topical therapy: brinzolamide, timolol
M	78	Corneal leukoma	PKP	Left eye trauma at 20 years old, arterial hypertension, diabetes mellitus type II, prostatic cancer
F	83	FECD	PKP	Allergies (penicillin, metamizole), arterial hypertension, hypercholesterolemia, hypothyroidism, depression	Topical therapy: indomethacina, bromfenac, edenorm
F	47	FECD	PKP	Postsurgical hypothyroidism
M	81	FECD	PKP	Arterial hypertension COPD, diabetes mellitus type II, benign prostatic hypertrophy	Topical therapy: netilmicin, dexamethasone, ofloxacin
M	40	Keratoconus	PKP	Allergies (pollen)
F	40	Pellucid marginal degeneration	PKP	Allergies (pollen)
F	77	FECD	PKP	Diabetes mellitus type II, diabetical neuropathy, acute myocardial infarction, kidney failure treated with transplant, HCV+	Topical therapy: brinzolamide, timolol, brimonidine
M	80	FECD	PKP	Arterial hypertension, keratoconus in the both eyes	Topical therapy: cloramphenicol dexamethasone, bluyal a
F	70	Corneal leukoma	PKP	Pontomesencephalic cavernoma
F	72	Corneal leukoma	PKP	Arterial hypertension, asthma, ulcerative rectocolitis	Topical therapy: trehalose, clobetasone
F	31	Keratoconus	PKP	Down’s syndrome, seasonal affective disorder
M	71	FECD	PKP
M	67	FECD	PKP	Parkinson’s disease, gastroesophageal reflux disease, benign prostatic hypertrophy, biliary stones, paranoid psychosis
F	24	Corneal leukoma	PKP	Acute myeloid leukemia in remission, seasonal affective disorder
M	75	Late failure of transplanted cornea	PKP	Arterial hypertension, benign prostatic hypertrophy
M	78	Late failure of transplanted cornea	PKP	Diabetes mellitus type II
F	21	Corneal leukoma (chemical burn)	PKP	Seasonal affective disorder
F	66	Corneal leukoma	PKP	Facio-scapular-humeral muscular dystrophy

COPD: chronic obstructive pulmonary disease; FECD: Fuchs’ endothelial corneal dystrophy; HCV: hepatitis C virus; PKP: penetrating keratoplasty.