Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs)

Figure 5

Increased expression of neuronal/glial lineage and neuroprotective genes in hRPCs after coculture with AMD cybrids. In hRPCs, coculture with AMD cybrids significantly increased the expression of (a) markers of neuronal (MAP2, , ) and (b) glial lineage (GFAP, , ) and neuroprotective factors (c) MDK (, ), (d) PTN (, ), and (e) FGF2 (, ) compared to hRPCs with age-matched normal cybrids. The relative quantification () was utilized for the data, and Tukey -test and Student -test (unpaired) were used for values between the two groups, with significance determined at . See Table 3.

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