Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects

<div>The therapeutic efficacy of primed MSCs in vivo. (a) The level of apoptosis was measured after the injection of naïve and primed MSCs into the lateral ventricle of mouse brains and expressed as a percentage of the WT controls. (b) Secreted amyloid-beta levels were measured by Western blots and expressed as a percentage of the WT controls. (c) The deposition of amyloid-beta in the cortex and hippocampus was visualized by thioflavin-S staining, and the intensity was measured and plotted as a histogram. Scale bar: 100 <i>μ</i>m. (d) The standard curve was fitted to the linear regression for real-time quantitative PCR (qPCR) analysis. (e) The absolute number of cells in the brains of mice in the naïve MSC and primed MSC groups was calculated. 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Stem Cells International

fig4

Figure 4

Figure 4: Exposure of Mesenchymal Stem Cells to an Alzheimer’s Disease Environment Enhances Therapeutic Effects 