Lithium and Copper Induce the Osteogenesis-Angiogenesis Coupling of Bone Marrow Mesenchymal Stem Cells via Crosstalk between Canonical Wnt and HIF-1<i>α</i> Signaling Pathways

<div>Li 2.5-Cu 1.0-HA/Col scaffold has good biocompatibility and could promote the secretion of osteogenesis and angiogenesis factors. (a, b) The proliferation and vitality of BMSC coculture with Li 2.5-Cu 1.0-HA/Col scaffolds tested by the MTS assay (days 1, 3, 5, and 7) and Live-Dead Cell staining (day 3). (c) ELISA analysis of the secretion of osteogenesis (ALP, OCN) and angiogenesis (VEGF) factors when BMSCs were cocultured with Li 2.5-Cu 1.0-HA/Col scaffolds.</div>

Stem Cells International

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Figure 3: Lithium and Copper Induce the Osteogenesis-Angiogenesis Coupling of Bone Marrow Mesenchymal Stem Cells via Crosstalk between Canonical Wnt and HIF-1<i>α</i> Signaling Pathways 

Figure 3 | Lithium and Copper Induce the Osteogenesis-Angiogenesis Coupling of Bone Marrow Mesenchymal Stem Cells via Crosstalk between Canonical Wnt and HIF-1α Signaling Pathways 