Electrical Stimulation Promotes Stem Cell Neural Differentiation in Tissue Engineering

Table 1

iPSCs and ESCs used in clinical trials for the treatment of nerve diseases.

Cell type/goal	Source	Disease	Phase	Trail number
Oligodendrocyte progenitor cell	Human brain	Demyelinating diseases	Unknown	NCT00283023
Human ESC-derived neural precursor cells	Human embryonic stem cells	Parkinson’s disease	Phase 2	NCT03119636
Development of iPSCs	Somatic cells of patients with neurological diseases	Neurodegenerative disorders	Recruiting	NCT00874783
Generate disease-specific iPSC lines	Neuro-degenerative disease patients	Neuro-degenerative disease	Recruiting	NCT03322306
Establishing of neuronal-like cells from iPSCs	PBMCs	Peripheral nervous system diseases	Withdrawn (lack of funding)	NCT02492360
Neurons and glia derived from iPSCs	Patients with genetic mutations responsible for neurological and neurodegenerative diseases	Neurodegenerative diseases	Not yet recruiting	NCT03682458
Develop human iPSCs	An existing collection of human somatic cells	Amyotrophic lateral sclerosis	Recruiting	NCT00801333
Establishment of human cellular disease models from iPSCs	Patient-derived fibroblasts	Wilson disease	Recruiting	NCT03867526
Neuronal distinction of iPSC	Human fibroblast with MYT1L mutation	Mental retardation	Completed	NCT02980302
Neuronal progenitors derived from iPSC	Blood sample	Rare intellectual disabilities	Recruiting	NCT03635294
Neural cells derived from iPSC	Patients’ skin	Niemann-pick diseases	Recruiting	NCT03883750
Establish an iPSC bank	Patients with NF1 mutations	Tumors in the central nervous system	Suspended	NCT03332030
Derivation of iPSC	Human somatic cells from existing collections	Amyotrophic lateral sclerosis	Recruiting	NCT00801333
Creation of a large repository of iPSC	Blood and spinal fluid (optional)	Amyotrophic lateral sclerosis	Completed	NCT02574390
Creation of a Bank of Fibroblast from iPSC	Skin biopsy	Amyotrophic lateral sclerosis	Completed	NCT01639391
Development of iPSC	Patients’ fibroblast	Neurodegenerative disorders	Recruiting	NCT00874783